File Name: clinical applications of circulating tumor cells and circulating tumor dna as liquid biopsy .zip
Ovarian cancer remains the most lethal disease among gynecological malignancies despite the plethora of research studies during the last decades.
As one of the most common malignant tumors worldwide, hepatocellular carcinoma HCC is known for its poor prognosis due to diagnosis only in advanced stages. Currently, the advancements in the integration of omics information have begun to transform the clinical management of cancer patients. Molecular profiling for HCC patients is in general obtained from resected tumor materials or biopsies.
Metrics details. Hepatocellular carcinoma HCC is a highly malignant disease with a poor prognosis and high mortality due to a low early diagnosis rate, resistance to systemic treatments and progression to late-stage liver disease. Thus, it is imperative to establish a novel diagnostic strategy with high sensitivity and reliability to monitor risk factors to detect HCC at an early stage. As a noninvasive detection method, liquid biopsy is expected to play an important role in the early diagnosis, dynamic monitoring of cancer patients and drug screening. In this review, we will focus on the clinical applications, recent studies and future prospects of liquid biopsy, particularly focusing on HCC. Hepatocellular carcinoma HCC is the fifth most common cancer worldwide and remains the third most frequent cause of cancer death, with nearly , deaths and , new cases reported in China [ 1 , 2 ].
One application of liquid biopsy technology is the diagnosis of disease using biomarkers found in blood, urine, stool, saliva, and other biological samples from patients. More recently, the use of cell-free DNA from plasma is emerging as an important minimally invasive tool for clinical diagnosis. The development of technology has increased the diversity of its application. Here, we discuss how liquid biopsies have been used in the clinic, and how personalized medicine are likely to use liquid biopsies in the near future. This is a preview of subscription content, access via your institution.
International Journal of Biological Sciences. Journal of Cancer. Journal of Genomics. Global reach, higher impact. Journal of Genomics - Submit manuscript now Int J Med Sci ; 13 12 Pancreatic cancer has a rather dismal prognosis mainly due to high malignance of tumor biology.
Colorectal cancer CRC is one of the most common gastrointestinal tumors and the second leading cause of cancer death worldwide. Since traditional biopsies are invasive and do not reflect tumor heterogeneity or monitor the dynamic progression of tumors, there is an urgent need for new noninvasive methods that can supplement and improve the current management strategies of CRC. Blood-based liquid biopsies are a promising noninvasive biomarker that can detect disease early, assist in staging, monitor treatment responses, and predict relapse and metastasis. Over time, an increasing number of experiments have indicated the clinical utility of liquid biopsies in CRC. In this review, we mainly focus on the development of circulating tumor cells and circulating tumor DNA as key components of liquid biopsies in CRC and introduce the potential of exosomal microRNAs as emerging liquid biopsy markers in clinical application for CRC. Colorectal cancer CRC is one of the most common gastrointestinal tumors and the second leading cause of cancer death worldwide [ 1 ].
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Pantel Published Medicine Cancer discovery. Analyses of CTCs and ctDNA have paved new diagnostic avenues and are, to date, the cornerstones of liquid biopsy diagnostics. View PDF. Save to Library.
Article · Figures & Data · Info & Metrics · PDF. Loading. Abstract. “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and areas of clinical applications of CTCs and ctDNA, including detection of cancer.
Circulating tumour cells CTCs refer to cells found in the peripheral blood, which are derived from the primary or secondary tumour. They serve as an alternative to study the biology of the primary tumour especially when tissue biopsy is not available.
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